You can only beat your head against the wall so many times before you crack, spilling your hopes onto the floor. You struggle to pay the price of existence, and the costs are staggering. Damaged and broken, you barely survive the day, and get no relief from a fitful sleep before waking up again. The cycle of hopelessness is not a circle but a downward spiral, a black hole from which positive things never escape. Your carefully constructed life is shattered by a disease with no empathy. The beast is not satisfied until its victims lie on the floor, crushed by its destructive power.
Swimming Upstream 
I know this spiral all too well beautifully said.